Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2.

Song, Jie; Baker, Nicola; Rothert, Monja; Henke, Björn; Jeacock, Laura; Horn, David; Beitz, Eric

Song, Jie; Baker, Nicola; Rothert, Monja; Henke, Björn; Jeacock, Laura; Horn, David; Beitz, Eric.

Afiliação

Song J; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Kiel, Germany.
Baker N; Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Rothert M; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Kiel, Germany.
Henke B; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Kiel, Germany.
Jeacock L; Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Horn D; Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
Beitz E; Department of Pharmaceutical and Medicinal Chemistry, Christian-Albrechts-University of Kiel, Kiel, Germany.

PLoS Pathog ; 12(2): e1005436, 2016 Feb.

Article em En | MEDLINE | ID: mdl-26828608

Assuntos

Aquagliceroporinas/metabolismo; Pentamidina/farmacologia; Tripanossomicidas/farmacologia; Trypanosoma brucei brucei/efeitos dos fármacos; Animais; Resistência a Medicamentos/genética; Humanos; Tripanossomíase Africana/tratamento farmacológico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pentamidina / Tripanossomicidas / Trypanosoma brucei brucei / Aquagliceroporinas Limite: Animals / Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

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