Intranasal vaccination with Î³-irradiated Streptococcus pneumoniae whole-cell vaccine provides serotype-independent protection mediated by B-cells and innate IL-17 responses.

Babb, Rachelle; Chen, Austen; Hirst, Timothy R; Kara, Ervin E; McColl, Shaun R; Ogunniyi, Abiodun D; Paton, James C; Alsharifi, Mohammed

Babb, Rachelle; Chen, Austen; Hirst, Timothy R; Kara, Ervin E; McColl, Shaun R; Ogunniyi, Abiodun D; Paton, James C; Alsharifi, Mohammed.

Afiliação

Babb R; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Chen A; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Hirst TR; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia Gamma Vaccines Pty Ltd, Mountbatten Park, Yarralumla, ACT 2600, Australia.
Kara EE; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
McColl SR; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Ogunniyi AD; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia.
Paton JC; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia mohammed.alsharifi@adelaide.edu.au james.paton@adelaide.edu.au.
Alsharifi M; Research Centre for Infectious Diseases, Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, SA 5005, Australia Gamma Vaccines Pty Ltd, Mountbatten Park, Yarralumla, ACT 2600, Australia mohammed.alsharifi@adelaide.edu.au james.paton@adelaide

Clin Sci (Lond) ; 130(9): 697-710, 2016 May.

Article em En | MEDLINE | ID: mdl-26831937

Assuntos

Linfócitos B/imunologia; Raios gama; Imunidade Inata; Interleucina-17/metabolismo; Vacinas Pneumocócicas/imunologia; Streptococcus pneumoniae/imunologia; Streptococcus pneumoniae/efeitos da radiação; Vacinação; Administração Intranasal; Animais; Linfócitos T CD4-Positivos/imunologia; Imunidade Inata/imunologia; Memória Imunológica; Interferon gama/metabolismo; Camundongos Endogâmicos C57BL; Infecções Pneumocócicas/complicações; Infecções Pneumocócicas/imunologia; Infecções Pneumocócicas/microbiologia; Infecções Pneumocócicas/prevenção & controle; Vacinas Pneumocócicas/administração & dosagem; Sepse/complicações; Sepse/imunologia; Sepse/microbiologia; Sepse/prevenção & controle; Sorotipagem; Streptococcus pneumoniae/classificação; Linfócitos T/imunologia; Resultado do Tratamento

Palavras-chave

Streptococcus pneumoniae; protective immunity; serotype independent; vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptococcus pneumoniae / Linfócitos B / Vacinação / Interleucina-17 / Vacinas Pneumocócicas / Raios gama / Imunidade Inata Limite: Animals Idioma: En Revista: Clin Sci (Lond) Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Austrália

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