Virus and Host Mechanics Support Membrane Penetration and Cell Entry.
J Virol
; 90(8): 3802-3805, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26842477
ABSTRACT
Viruses are quasi-inert macromolecular assemblies. Their metastable conformation changes during entry into cells, when chemical and mechanical host cues expose viral membrane-interacting proteins. This leads to membrane rupture or fusion and genome uncoating. Importantly, virions tune their physical properties and enhance penetration and uncoating. For example, influenza virus softens at low pH to uncoat. The stiffness and pressure of adenovirus control uncoating and membrane penetration. Virus and host mechanics thus present new opportunities for antiviral therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Ligação Viral
/
Internalização do Vírus
Idioma:
En
Revista:
J Virol
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Suíça