Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.

Guo, Weirui; Molinaro, Gemma; Collins, Katie A; Hays, Seth A; Paylor, Richard; Worley, Paul F; Szumlinski, Karen K; Huber, Kimberly M

Guo, Weirui; Molinaro, Gemma; Collins, Katie A; Hays, Seth A; Paylor, Richard; Worley, Paul F; Szumlinski, Karen K; Huber, Kimberly M.

Afiliação

Guo W; University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas 75390.
Molinaro G; University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas 75390.
Collins KA; University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas 75390.
Hays SA; University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas 75390.
Paylor R; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, and.
Worley PF; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Szumlinski KK; Department of Psychological and Brain Sciences, Neuroscience Research Institute, University of California, Santa Barbara, California 93106.
Huber KM; University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas 75390, Kimberly.Huber@UTSouthwestern.edu.

J Neurosci ; 36(7): 2131-47, 2016 Feb 17.

Article em En | MEDLINE | ID: mdl-26888925

Assuntos

Proteínas de Transporte/genética; Síndrome do Cromossomo X Frágil/genética; Síndrome do Cromossomo X Frágil/fisiopatologia; Receptor de Glutamato Metabotrópico 5/genética; Animais; Proteína do X Frágil da Deficiência Intelectual/genética; Técnicas de Introdução de Genes; Proteínas de Arcabouço Homer; Técnicas In Vitro; Sistema de Sinalização das MAP Quinases; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neocórtex/metabolismo; Fenótipo; Convulsões/genética; Convulsões/fisiopatologia; Filtro Sensorial

Palavras-chave

Homer; LTD; UP states; fragile X syndrome; mGluR5; protein synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Receptor de Glutamato Metabotrópico 5 / Síndrome do Cromossomo X Frágil Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2016 Tipo de documento: Article

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