Reduction of autophagy markers mediated protective effects of JNK inhibitor and bucladesine on memory deficit induced by Aß in rats.

Mohammadi, M; Guan, J; Khodagholi, F; Yans, A; Khalaj, S; Gholami, M; Taghizadeh, G H; Aliaghaei, A; Abdollahi, M; Ghahremani, M H; Sharifzadeh, M

Mohammadi, M; Guan, J; Khodagholi, F; Yans, A; Khalaj, S; Gholami, M; Taghizadeh, G H; Aliaghaei, A; Abdollahi, M; Ghahremani, M H; Sharifzadeh, M.

Afiliação

Mohammadi M; Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran.
Guan J; Liggins Institute, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand.
Khodagholi F; Centre for Brain Research, Faculty of Medicine and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand.
Yans A; Gravida National Centre for Growth and Development, University of Auckland, Auckland, New Zealand.
Khalaj S; Neuroscience Research Centre, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Gholami M; Neurobiology Research Centre, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Taghizadeh GH; Neuroscience Research Centre, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Aliaghaei A; Neurobiology Research Centre, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
Abdollahi M; Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran.
Ghahremani MH; Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran.
Sharifzadeh M; Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran.

Naunyn Schmiedebergs Arch Pharmacol ; 389(5): 501-10, 2016 May.

Article em En | MEDLINE | ID: mdl-26899864

Assuntos

Antracenos/uso terapêutico; Bucladesina/uso terapêutico; Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores; Transtornos da Memória/tratamento farmacológico; Fármacos Neuroprotetores/uso terapêutico; Inibidores de Proteínas Quinases/uso terapêutico; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides; Animais; Antracenos/farmacologia; Autofagia/efeitos dos fármacos; Proteína 12 Relacionada à Autofagia/metabolismo; Proteína 7 Relacionada à Autofagia/metabolismo; Proteína Beclina-1/metabolismo; Bucladesina/farmacologia; Modelos Animais de Doenças; Quimioterapia Combinada; Masculino; Aprendizagem em Labirinto/efeitos dos fármacos; Transtornos da Memória/metabolismo; Proteínas Associadas aos Microtúbulos/metabolismo; Fármacos Neuroprotetores/farmacologia; Inibidores de Proteínas Quinases/farmacologia; Ratos Wistar; Memória Espacial/efeitos dos fármacos

Palavras-chave

Alzheimer disease; Amyloid beta (Aß); Autophagy; Bucladesine; SP600125

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bucladesina / Fármacos Neuroprotetores / Proteínas Quinases JNK Ativadas por Mitógeno / Inibidores de Proteínas Quinases / Transtornos da Memória / Antracenos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Irã

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