Galectins and Immune Responses-Just How Do They Do Those Things They Do?
Annu Rev Immunol
; 34: 243-64, 2016 05 20.
Article
em En
| MEDLINE
| ID: mdl-26907217
ABSTRACT
Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell types. Galectins can function intracellularly and can also be secreted to bind to cell surface glycoconjugate counterreceptors. Some galectins are made by immune cells, whereas other galectins are secreted by different cell types, such as endothelial or epithelial cells, and bind to immune cells to regulate immune responses. Galectin binding to a single glycan ligand is a low-affinity interaction, but the multivalency of galectins and the glycan ligands presented on cell surface glycoproteins results in high-avidity binding that can reversibly scaffold or cluster these glycoproteins. Galectin binding to a specific glycoprotein counterreceptor is regulated in part by the repertoire of glycosyltransferase enzymes (which make the glycan ligands) expressed by that cell, and the effect of galectin binding results from clustering or retention of specific glycoprotein counterreceptors bearing these specific ligands.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicosiltransferases
/
Galectinas
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Imunidade
Limite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Ano de publicação:
2016
Tipo de documento:
Article