Associations between adiposity and indicators of thyroid status in children and adolescents.
Pediatr Obes
; 11(6): 551-558, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-26910299
ABSTRACT
BACKGROUND:
In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts.OBJECTIVES:
To examine associations of weight and adiposity with indices of thyroid function and thyroid-related metabolic factors in children. DESIGN/METHODS:
A sample of 1203 children without obesity (body mass index [BMI] < 95th percentile; N = 631) and with obesity (BMI ≥ 95th percentile; N = 572), age 5-18 years, had height and weight measured (to calculate BMI-Z score for age and sex) and had blood collected in the morning for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and leptin. A subset (N = 829) also underwent measurement of fat mass by dual-energy X-ray absorptiometry. Analyses examined associations of TSH and FT4 with adiposity and obesity-related conditions accounting for sociodemographic factors.RESULTS:
Thyroid-stimulating hormone was positively related to BMIz and fat mass (both p-values < 0.001). FT4 was negatively related to BMIz and fat mass (both p-values < 0.001). TSH was positively correlated to leptin (p = 0.001) even after accounting for fat mass.CONCLUSIONS:
Paediatric obesity is associated with higher TSH and lower FT4 concentrations and with a greater prevalence of abnormally high TSH. Leptin concentrations may in part explain obesity's effects on thyroid status, perhaps through leptin's effects on TSH secretion.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Tiroxina
/
Tireotropina
/
Leptina
/
Adiposidade
/
Obesidade Infantil
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Child
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Female
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Obes
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos