Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients.

Dornbusch, Juana; Walter, Martina; Gottschalk, Andrea; Obaje, Alice; Junker, Kerstin; Ohlmann, Carsten-Henning; Meinhardt, Matthias; Zacharis, Aristeidis; Zastrow, Stefan; Schoffer, Olaf; Grimm, Marc-Oliver; Klug, Stefanie J; Wirth, Manfred P; Fuessel, Susanne

Dornbusch, Juana; Walter, Martina; Gottschalk, Andrea; Obaje, Alice; Junker, Kerstin; Ohlmann, Carsten-Henning; Meinhardt, Matthias; Zacharis, Aristeidis; Zastrow, Stefan; Schoffer, Olaf; Grimm, Marc-Oliver; Klug, Stefanie J; Wirth, Manfred P; Fuessel, Susanne.

Afiliação

Dornbusch J; Department of Urology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Walter M; Department of Urology, University Hospital of Jena, Lessingstr. 1, 07743, Jena, Germany.
Gottschalk A; Institute for Medical Informatics and Biometry, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Obaje A; Department of Urology, University Hospital of Jena, Lessingstr. 1, 07743, Jena, Germany.
Junker K; Department of Urology, Saarland University Medical Center, Kirrberger Str. 1, 66424, Homburg, Germany.
Ohlmann CH; Department of Urology, Saarland University Medical Center, Kirrberger Str. 1, 66424, Homburg, Germany.
Meinhardt M; Institute of Pathology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Zacharis A; Department of Urology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Zastrow S; Department of Urology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Schoffer O; Cancer Epidemiology, University Cancer Center Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Grimm MO; Department of Urology, University Hospital of Jena, Lessingstr. 1, 07743, Jena, Germany.
Klug SJ; Cancer Epidemiology, University Cancer Center Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Wirth MP; Department of Urology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Fuessel S; Department of Urology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany. susanne.fuessel@uniklinikum-dresden.de.

J Cancer Res Clin Oncol ; 142(6): 1171-82, 2016 Jun.

Article em En | MEDLINE | ID: mdl-26935927

Assuntos

Antineoplásicos/uso terapêutico; Biomarcadores Tumorais/genética; Carcinoma de Células Renais/tratamento farmacológico; Indóis/uso terapêutico; Neoplasias Renais/tratamento farmacológico; Neovascularização Patológica/genética; Polimorfismo de Nucleotídeo Único; Pirróis/uso terapêutico; Receptores de Fatores de Crescimento do Endotélio Vascular/genética; Fator A de Crescimento do Endotélio Vascular/genética; Idoso; Inibidores da Angiogênese/uso terapêutico; Carcinoma de Células Renais/genética; Carcinoma de Células Renais/patologia; Feminino; Humanos; Neoplasias Renais/genética; Neoplasias Renais/patologia; Masculino; Pessoa de Meia-Idade; Metástase Neoplásica; Prognóstico; Sunitinibe

Palavras-chave

FLT1; FLT4; KDR; SNP; Sunitinib; VEGFA; VEGFR; mRCC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirróis / Carcinoma de Células Renais / Biomarcadores Tumorais / Polimorfismo de Nucleotídeo Único / Receptores de Fatores de Crescimento do Endotélio Vascular / Fator A de Crescimento do Endotélio Vascular / Indóis / Neoplasias Renais / Neovascularização Patológica / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cancer Res Clin Oncol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

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