Identification of the non-ribosomal peptide synthetase responsible for biosynthesis of the potential anti-cancer drug sansalvamide in Fusarium solani.

Romans-Fuertes, Patricia; Sondergaard, Teis Esben; Sandmann, Manuela Ilse Helga; Wollenberg, Rasmus Dam; Nielsen, Kristian Fog; Hansen, Frederik T; Giese, Henriette; Brodersen, Ditlev Egeskov; Sørensen, Jens Laurids

Romans-Fuertes, Patricia; Sondergaard, Teis Esben; Sandmann, Manuela Ilse Helga; Wollenberg, Rasmus Dam; Nielsen, Kristian Fog; Hansen, Frederik T; Giese, Henriette; Brodersen, Ditlev Egeskov; Sørensen, Jens Laurids.

Afiliação

Romans-Fuertes P; Department of Molecular Biology and Genetics, NANORIPES Centre for Natural Non-Ribosomal Peptide Synthesis, Aarhus University, Gustav Wieds Vej 10c, 8000, Aarhus C, Denmark.
Sondergaard TE; Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg East, Denmark.
Sandmann MI; Department of Molecular Biology and Genetics, NANORIPES Centre for Natural Non-Ribosomal Peptide Synthesis, Aarhus University, Gustav Wieds Vej 10c, 8000, Aarhus C, Denmark.
Wollenberg RD; Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg East, Denmark.
Nielsen KF; Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg East, Denmark.
Hansen FT; Department of Chemistry and Bioscience, Aalborg University, Fredrik Bajers Vej 7H, 9220, Aalborg East, Denmark.
Giese H; Department of Systems Biology, Technical University of Denmark, Søltofts Plads, Bygning 221, 2800, Kgs. Lyngby, Denmark.
Brodersen DE; Department of Molecular Biology and Genetics, NANORIPES Centre for Natural Non-Ribosomal Peptide Synthesis, Aarhus University, Gustav Wieds Vej 10c, 8000, Aarhus C, Denmark.
Sørensen JL; Department of Molecular Biology and Genetics, NANORIPES Centre for Natural Non-Ribosomal Peptide Synthesis, Aarhus University, Gustav Wieds Vej 10c, 8000, Aarhus C, Denmark.

Curr Genet ; 62(4): 799-807, 2016 Nov.

Article em En | MEDLINE | ID: mdl-26936154

Assuntos

Depsipeptídeos/biossíntese; Depsipeptídeos/farmacologia; Fusarium/genética; Fusarium/metabolismo; Peptídeo Sintases/genética; Peptídeo Sintases/metabolismo; Antineoplásicos; Depsipeptídeos/química; Regulação Fúngica da Expressão Gênica; Genoma Fúngico; Metaboloma; Metabolômica; Modelos Biológicos; Família Multigênica; Filogenia; Metabolismo Secundário; Deleção de Sequência; Transcrição Gênica

Palavras-chave

Agrobacterium tumefaciens-mediated transformation; Destruxin; Metarhizium robertsii; NRPS; Nectria haematococca; Secondary metabolites

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeo Sintases / Depsipeptídeos / Fusarium Tipo de estudo: Diagnostic_studies Idioma: En Revista: Curr Genet Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Dinamarca

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