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Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design.
Dorywalska, Magdalena; Dushin, Russell; Moine, Ludivine; Farias, Santiago E; Zhou, Dahui; Navaratnam, Thayalan; Lui, Victor; Hasa-Moreno, Adela; Casas, Meritxell Galindo; Tran, Thomas-Toan; Delaria, Kathy; Liu, Shu-Hui; Foletti, Davide; O'Donnell, Christopher J; Pons, Jaume; Shelton, David L; Rajpal, Arvind; Strop, Pavel.
Afiliação
  • Dorywalska M; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Dushin R; Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut.
  • Moine L; Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut.
  • Farias SE; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Zhou D; Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut.
  • Navaratnam T; Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut.
  • Lui V; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Hasa-Moreno A; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Casas MG; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Tran TT; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Delaria K; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Liu SH; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Foletti D; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • O'Donnell CJ; Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut.
  • Pons J; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Shelton DL; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Rajpal A; Rinat Laboratories, Pfizer Inc., South San Francisco, California.
  • Strop P; Rinat Laboratories, Pfizer Inc., South San Francisco, California. pavel.strop@bms.com.
Mol Cancer Ther ; 15(5): 958-70, 2016 05.
Article em En | MEDLINE | ID: mdl-26944918
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valina / Carbamatos / Citrulina / Imunoconjugados / Anticorpos Monoclonais / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valina / Carbamatos / Citrulina / Imunoconjugados / Anticorpos Monoclonais / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2016 Tipo de documento: Article