DNA methylation profiling in human Huntington's disease brain.

De Souza, Rebecca A G; Islam, Sumaiya A; McEwen, Lisa M; Mathelier, Anthony; Hill, Austin; Mah, Sarah M; Wasserman, Wyeth W; Kobor, Michael S; Leavitt, Blair R

De Souza, Rebecca A G; Islam, Sumaiya A; McEwen, Lisa M; Mathelier, Anthony; Hill, Austin; Mah, Sarah M; Wasserman, Wyeth W; Kobor, Michael S; Leavitt, Blair R.

Afiliação

De Souza RA; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4 rdesouza@cmmt.ubc.ca.
Islam SA; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
McEwen LM; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Mathelier A; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Hill A; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Mah SM; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Wasserman WW; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Kobor MS; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
Leavitt BR; Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

Hum Mol Genet ; 25(10): 2013-2030, 2016 05 15.

Article em En | MEDLINE | ID: mdl-26953320

Assuntos

Metilação de DNA/genética; Epigenômica; Proteína Huntingtina/genética; Doença de Huntington/genética; Proteínas Repressoras/genética; Adulto; Idoso; Sítios de Ligação; Fator de Ligação a CCCTC; Córtex Cerebelar/metabolismo; Córtex Cerebelar/patologia; Proteínas de Ligação a DNA/genética; Feminino; Regulação da Expressão Gênica; Humanos; Proteína Huntingtina/metabolismo; Doença de Huntington/patologia; Masculino; Pessoa de Meia-Idade; Especificidade de Órgãos; Regiões Promotoras Genéticas; Ligação Proteica; Proteínas Repressoras/metabolismo

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Doença de Huntington / Metilação de DNA / Epigenômica / Proteína Huntingtina Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2016 Tipo de documento: Article

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