Risk of neurodevelopmental impairment for outborn extremely preterm infants in an Australian regional network.
J Matern Fetal Neonatal Med
; 30(1): 96-102, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-26957041
ABSTRACT
OBJECTIVE:
To compare neurodevelopmental outcomes at 2-3 years in extremely premature outborn and inborn infants.DESIGN:
Population-based retrospective cohort study.SETTING:
Geographically defined area of New South Wales (NSW) and the Australian Capital Territory (ACT) served by a network of 10 neonatal intensive care units (NICUs). PATIENTS All premature infants <29 weeks gestation born between 1998 and 2004 in the setting. INTERVENTION At 2-3 years, corrected age, 1473 children were assessed with either the Griffiths Mental Developmental Scales (GMDS) or the Bayley Scales of Infant Development (BSID-II). MAIN OUTCOMEMEASURE:
Moderate/severe functional disability (FD) defined as developmental delay (GMDS general quotient (GQ) or BSID-II mental developmental index (MDI)) > 2 standard deviations (SD) below the mean; cerebral palsy (CP) requiring aids; sensorineural or conductive deafness (requiring amplification); or bilateral blindness (visual acuity <6/60 in better eye).RESULTS:
At 2-3 years, moderate/severe functional disability does not appear to be significantly different between outborn and inborn infants (adjusted OR 0.782; 95% CI 0.424-1.443). However, there were a significant number of outborn infants lost to follow up (23.3% versus 42.9%).CONCLUSION:
In this cohort, at 2-3 years follow up neurodevelopmental outcome does not appear to be significantly different between outborn and inborn infants. These results should be interpreted with caution given the limitation of this study.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Intensiva Neonatal
/
Paralisia Cerebral
/
Deficiências do Desenvolvimento
/
Cegueira
/
Surdez
/
Lactente Extremamente Prematuro
/
Doenças do Prematuro
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
/
Newborn
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Assunto da revista:
OBSTETRICIA
/
PERINATOLOGIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Austrália