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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
Ellinghaus, David; Jostins, Luke; Spain, Sarah L; Cortes, Adrian; Bethune, Jörn; Han, Buhm; Park, Yu Rang; Raychaudhuri, Soumya; Pouget, Jennie G; Hübenthal, Matthias; Folseraas, Trine; Wang, Yunpeng; Esko, Tonu; Metspalu, Andres; Westra, Harm-Jan; Franke, Lude; Pers, Tune H; Weersma, Rinse K; Collij, Valerie; D'Amato, Mauro; Halfvarson, Jonas; Jensen, Anders Boeck; Lieb, Wolfgang; Degenhardt, Franziska; Forstner, Andreas J; Hofmann, Andrea; Schreiber, Stefan; Mrowietz, Ulrich; Juran, Brian D; Lazaridis, Konstantinos N; Brunak, Søren; Dale, Anders M; Trembath, Richard C; Weidinger, Stephan; Weichenthal, Michael; Ellinghaus, Eva; Elder, James T; Barker, Jonathan N W N; Andreassen, Ole A; McGovern, Dermot P; Karlsen, Tom H; Barrett, Jeffrey C; Parkes, Miles; Brown, Matthew A; Franke, Andre.
Afiliação
  • Ellinghaus D; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
  • Jostins L; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Spain SL; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Cortes A; Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Bethune J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Han B; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
  • Park YR; Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
  • Raychaudhuri S; Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
  • Pouget JG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Hübenthal M; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Folseraas T; Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Wang Y; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Esko T; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Metspalu A; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Westra HJ; Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
  • Franke L; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Pers TH; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Weersma RK; Research Institute of Internal Medicine, Division of Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
  • Collij V; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
  • D'Amato M; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
  • Halfvarson J; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Jensen AB; Division of Endocrinology, Boston Children's Hospital, Cambridge, Massachusetts, USA.
  • Lieb W; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge, Massachusetts, USA.
  • Degenhardt F; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Forstner AJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Hofmann A; Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Schreiber S; Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
  • Mrowietz U; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  • Juran BD; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
  • Lazaridis KN; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
  • Brunak S; Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden.
  • Dale AM; BioCruces Health Research Institute and Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
  • Trembath RC; Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
  • Weidinger S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Weichenthal M; Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Ellinghaus E; PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Elder JT; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Barker JN; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
  • Andreassen OA; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • McGovern DP; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
  • Karlsen TH; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Barrett JC; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
Nat Genet ; 48(5): 510-8, 2016 05.
Article em En | MEDLINE | ID: mdl-26974007
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Espondilite Anquilosante / Colangite Esclerosante / Colite Ulcerativa / Doença de Crohn / Pleiotropia Genética / Inflamação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Espondilite Anquilosante / Colangite Esclerosante / Colite Ulcerativa / Doença de Crohn / Pleiotropia Genética / Inflamação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha