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Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Harriman, Geraldine; Greenwood, Jeremy; Bhat, Sathesh; Huang, Xinyi; Wang, Ruiying; Paul, Debamita; Tong, Liang; Saha, Asish K; Westlin, William F; Kapeller, Rosana; Harwood, H James.
Afiliação
  • Harriman G; Nimbus Therapeutics, Cambridge, MA 02141;
  • Greenwood J; Schrodinger Inc., New York, NY 10036;
  • Bhat S; Schrodinger Inc., New York, NY 10036;
  • Huang X; Pharmaron Beijing Co. Ltd., Beijing 100176, China;
  • Wang R; Department of Biological Sciences, Columbia University, New York, NY 10027;
  • Paul D; Department of Biological Sciences, Columbia University, New York, NY 10027;
  • Tong L; Department of Biological Sciences, Columbia University, New York, NY 10027;
  • Saha AK; Department of Medicine and Physiology, School of Medicine, Endocrinology, Diabetes, and Nutrition, Boston University, Boston, MA 02118.
  • Westlin WF; Nimbus Therapeutics, Cambridge, MA 02141;
  • Kapeller R; Nimbus Therapeutics, Cambridge, MA 02141;
  • Harwood HJ; Nimbus Therapeutics, Cambridge, MA 02141; h.james.harwood@gmail.com.
Proc Natl Acad Sci U S A ; 113(13): E1796-805, 2016 Mar 29.
Article em En | MEDLINE | ID: mdl-26976583
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetil-CoA Carboxilase / Pirimidinonas / Tiofenos / Inibidores Enzimáticos / Dislipidemias / Fígado Gorduroso Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetil-CoA Carboxilase / Pirimidinonas / Tiofenos / Inibidores Enzimáticos / Dislipidemias / Fígado Gorduroso Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2016 Tipo de documento: Article