Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes.

Ackermann, Amanda M; Wang, Zhiping; Schug, Jonathan; Naji, Ali; Kaestner, Klaus H

Ackermann, Amanda M; Wang, Zhiping; Schug, Jonathan; Naji, Ali; Kaestner, Klaus H.

Afiliação

Ackermann AM; Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA; Institute of Diabetes, Obesity, and Metabolism, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address: ack
Wang Z; Institute for Biomedical Informatics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address: zhipwang@mail.med.upenn.edu.
Schug J; Institute of Diabetes, Obesity, and Metabolism, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA; Department of Genetics, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address: jschug@upenn.edu.
Naji A; Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address: ali.naji@uphs.upenn.edu.
Kaestner KH; Institute of Diabetes, Obesity, and Metabolism, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA; Department of Genetics, The University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia 19104, PA, USA. Electronic address: kaestner@mail.med.upenn.edu.

Mol Metab ; 5(3): 233-244, 2016 Mar.

Article em En | MEDLINE | ID: mdl-26977395

Palavras-chave

ARX, aristaless related homeobox; ATAC-seq, Assay for Transposase-Accessible Chromatin with high throughput sequencing; Alpha cell; Beta cell; CHODL, chondrolectin; ChIP-seq, Chromatin Immunoprecipitation followed by high throughput sequencing; DAPI, 4',6-diamidino-2-phenylindole; DPP4, dipeptidyl-peptidase 4; Diabetes; Epigenetics; FACS, fluorescence-activated cell sorting; FAIRE-seq, Formaldehyde-Assisted Isolation of Regulatory Elements followed by high throughput sequencing; GC, group-specific protein; GCG, glucagon; GHRL, ghrelin; IGF2, insulin like growth factor 2; INS, insulin; IRX2, iroquois homeobox 2; Islet; MAFA, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; NEUROD1, neuronal differentiation 1; Open chromatin; PP, pancreatic polypeptide; SNP, single nucleotide polymorphism; SST, somatostatin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Metab Ano de publicação: 2016 Tipo de documento: Article

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