Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans.
J Neurosci
; 36(11): 3157-69, 2016 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-26985027
ABSTRACT
Food availability and nutritional status are important cues affecting behavioral states. Here we report that, in Caenorhabditis elegans, a cascade of dopamine and neuropeptide signaling acts to inhibit nociception in food-poor environments. In the absence of food, animals show decreased sensitivity and increased adaptation to soluble repellents sensed by the polymodal ASH nociceptors. The effects of food on adaptation are affected by dopamine and neuropeptide signaling; dopamine acts via the DOP-1 receptor to decrease adaptation on food, whereas the neuropeptide receptors NPR-1 and NPR-2 act to increase adaptation off food. NPR-1 and NPR-2 function cell autonomously in the ASH neurons to increase adaptation off food, whereas the DOP-1 receptor controls neuropeptide release from interneurons that modulate ASH activity indirectly. These results indicate that feeding state modulates nociception through the interaction of monoamine and neuropeptide signaling pathways.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
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Adaptação Fisiológica
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Transdução de Sinais
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Comportamento Alimentar
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Nociceptividade
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2016
Tipo de documento:
Article