Genetic analysis of five children with essential thrombocytosis identified mutations in cancer-associated genes with roles in transcriptional regulation.

Kucine, Nicole; Viny, Aaron D; Rampal, Raajit; Berger, Michael; Socci, Nicholas; Viale, Agnes; Bussel, James B; Levine, Ross L; Rapaport, Franck

Kucine, Nicole; Viny, Aaron D; Rampal, Raajit; Berger, Michael; Socci, Nicholas; Viale, Agnes; Bussel, James B; Levine, Ross L; Rapaport, Franck.

Afiliação

Kucine N; Department of Pediatrics, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA nik9015@med.cornell.edu.
Viny AD; Human Oncology and Pathogenesis Program; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Rampal R; Human Oncology and Pathogenesis Program; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Berger M; Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Socci N; Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Viale A; Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Bussel JB; Department of Pediatrics, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, USA.
Levine RL; Human Oncology and Pathogenesis Program; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Rapaport F; Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Haematologica ; 101(6): e237-9, 2016 06.

Article em En | MEDLINE | ID: mdl-26992943

Assuntos

Genes Neoplásicos; Mutação; Trombocitemia Essencial/genética; Transcrição Gênica; Adolescente; Adulto; Criança; Pré-Escolar; Análise Mutacional de DNA/métodos; Feminino; Humanos

Palavras-chave

chronic myeloproliferative disorders; cytogenetics and molecular genetics; pediatric

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Genes Neoplásicos / Trombocitemia Essencial / Mutação Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans Idioma: En Revista: Haematologica Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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