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Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors.
Kavanagh, Madeline E; Coyne, Anthony G; McLean, Kirsty J; James, Guy G; Levy, Colin W; Marino, Leonardo B; de Carvalho, Luiz Pedro S; Chan, Daniel S H; Hudson, Sean A; Surade, Sachin; Leys, David; Munro, Andrew W; Abell, Chris.
Afiliação
  • Kavanagh ME; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.
  • Coyne AG; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.
  • McLean KJ; Centre for Synthetic Biology of Fine and Specialty Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K.
  • James GG; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.
  • Levy CW; Centre for Synthetic Biology of Fine and Specialty Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K.
  • Marino LB; Laboratory of Mycobacterial Metabolism and Antibiotic Research, Francis Crick Institute, The Mill Hill Laboratory , London NW7 1AA, U.K.
  • de Carvalho LP; School of Pharmaceutical Sciences, São Paulo State University (UNESP) , 4801-902 Araraquara, SP, Brazil.
  • Chan DS; Laboratory of Mycobacterial Metabolism and Antibiotic Research, Francis Crick Institute, The Mill Hill Laboratory , London NW7 1AA, U.K.
  • Hudson SA; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.
  • Surade S; Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.
  • Leys D; Department of Biochemistry, University of Cambridge , 80 Tennis Court Road, Cambridge CB2 1GA U.K.
  • Munro AW; Centre for Synthetic Biology of Fine and Specialty Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K.
  • Abell C; Centre for Synthetic Biology of Fine and Specialty Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester , 131 Princess Street, Manchester M1 7DN, U.K.
J Med Chem ; 59(7): 3272-302, 2016 Apr 14.
Article em En | MEDLINE | ID: mdl-27002486
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Tuberculose / Desenho de Fármacos / Sistema Enzimático do Citocromo P-450 / Inibidores Enzimáticos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Tuberculose / Desenho de Fármacos / Sistema Enzimático do Citocromo P-450 / Inibidores Enzimáticos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido