Back on the scent: the olfactory system in CNS demyelinating diseases.
J Neurol Neurosurg Psychiatry
; 87(10): 1146-54, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27003274
ABSTRACT
Olfactory dysfunction is recognised across an ever broadening spectrum of neuropsychiatric conditions including central nervous system (CNS) demyelinating diseases such as multiple sclerosis (MS) and neuromyelitis optica (NMO). In this review, we unravel the striking evidence highlighting how olfactory loss is a common clinical feature in MS and NMO. We provide an overview of the supportive psychophysical, electrophysiological, radiological and pathological data that point to the anatomical substrate of olfactory deficits in these diseases. The pattern of underlying pathology affecting the olfactory system is shown to be complex, involving multiple structures that are affected in different ways throughout the course of the disease. This review is the first to synthesise the expanding body of literature on the topic, provides novel insight into the way in which the olfactory system is affected in CNS demyelinating diseases, and raises intriguing questions about the role of this system in the pathogenesis of these diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condutos Olfatórios
/
Olfato
/
Neuromielite Óptica
/
Doenças Desmielinizantes
/
Transtornos do Olfato
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido