Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling.

Zhang, Jin; Heimbach, Tycho; Scheer, Nico; Barve, Avantika; Li, Wenkui; Lin, Wen; He, Handan

Zhang, Jin; Heimbach, Tycho; Scheer, Nico; Barve, Avantika; Li, Wenkui; Lin, Wen; He, Handan.

Afiliação

Zhang J; Drug Metabolism & Pharmacokinetics Department, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936.
Heimbach T; Drug Metabolism & Pharmacokinetics Department, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936.
Scheer N; Business Development Department, CEVEC Pharmaceuticals GmbH, Cologne 51105, Germany.
Barve A; Drug Metabolism & Pharmacokinetics Department, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936.
Li W; Drug Metabolism & Pharmacokinetics Department, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936.
Lin W; Drug Metabolism & Pharmacokinetics Department, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936.
He H; Drug Metabolism & Pharmacokinetics Department, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936. Electronic address: handan.he@novartis.com.

J Pharm Sci ; 105(4): 1398-404, 2016 Apr.

Article em En | MEDLINE | ID: mdl-27019957

Assuntos

Fármacos Anti-HIV/farmacocinética; Citocromo P-450 CYP3A/metabolismo; Animais; Fármacos Anti-HIV/química; Fármacos Anti-HIV/metabolismo; Simulação por Computador; Inibidores do Citocromo P-450 CYP3A/farmacologia; Interações Medicamentosas; Humanos; Fígado/efeitos dos fármacos; Fígado/metabolismo; Masculino; Camundongos; Modelos Biológicos; Ritonavir/farmacologia

Palavras-chave

CYP enzymes; clinical pharmacokinetics; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fármacos Anti-HIV / Citocromo P-450 CYP3A Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: J Pharm Sci Ano de publicação: 2016 Tipo de documento: Article

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