Glutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia-Induced vascular dementia of rats.
Neurosci Lett
; 620: 169-76, 2016 05 04.
Article
em En
| MEDLINE
| ID: mdl-27040427
ABSTRACT
Chronic cerebral ischemia (CCI) is associated with cognitive decline in aging, vascular dementia and Alzheimer's disease. Substantial evidence has shown that chronic cerebral ischemia may cause cognitive impairment, but the underlying neurobiological mechanism is poorly understood so far. In the present study, we used a rat model of chronic cerebral ischemia by permanent bilateral common carotid artery occlusion (BCCAO) to investigate the alterations of glutamatergic and central cholinergic dysfunction, and their causal relationship with the cognitive deficits induced by chronic cerebral ischemia. We found that BCCAO rats exhibited spatial learning and memory impairments dysfunction 3 month after BCCAO. Meanwhile, vGluT levels as well as glutamatergic and central cholinergic positive neurons in the hippocampus CA1-3 field significantly decreased. The protection of glutamergic and cholinergic neurons or regulating glutamate and central cholinergic levels in hippocampal subregion may have beneficial effects on cognitive impairments associated with the possible mechanism in CCI-induced vascular dementia.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Demência Vascular
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Isquemia Encefálica
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Proteínas Vesiculares de Transporte de Acetilcolina
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Proteínas Vesiculares de Transporte de Glutamato
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Proteínas Vesiculares de Transporte de Aminoácidos Inibidores
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Região CA1 Hipocampal
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Região CA2 Hipocampal
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Região CA3 Hipocampal
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Aprendizagem Espacial
/
Memória
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2016
Tipo de documento:
Article