An ultra-deep sequencing strategy to detect sub-clonal TP53 mutations in presentation chronic lymphocytic leukaemia cases using multiple polymerases.

Worrillow, L; Baskaran, P; Care, M A; Varghese, A; Munir, T; Evans, P A; O'Connor, S J; Rawstron, A; Hazelwood, L; Tooze, R M; Hillmen, P; Newton, D J

Worrillow, L; Baskaran, P; Care, M A; Varghese, A; Munir, T; Evans, P A; O'Connor, S J; Rawstron, A; Hazelwood, L; Tooze, R M; Hillmen, P; Newton, D J.

Afiliação

Worrillow L; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Baskaran P; Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tuebingen, Germany.
Care MA; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Varghese A; Haematological Malignancy Diagnostic Services, Leeds Teaching Hospitals National Health Services Trust, Leeds, UK.
Munir T; Haematological Malignancy Diagnostic Services, Leeds Teaching Hospitals National Health Services Trust, Leeds, UK.
Evans PA; Haematological Malignancy Diagnostic Services, Leeds Teaching Hospitals National Health Services Trust, Leeds, UK.
O'Connor SJ; Haematological Malignancy Diagnostic Services, Leeds Teaching Hospitals National Health Services Trust, Leeds, UK.
Rawstron A; Haematological Malignancy Diagnostic Services, Leeds Teaching Hospitals National Health Services Trust, Leeds, UK.
Hazelwood L; Cancer Research UK, Ling Ka Shing Centre, University of Cambridge, Cambridge, UK.
Tooze RM; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Hillmen P; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
Newton DJ; Section of Experimental Haematology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.

Oncogene ; 35(40): 5328-5336, 2016 10 06.

Article em En | MEDLINE | ID: mdl-27041575

Assuntos

Sequenciamento de Nucleotídeos em Larga Escala/métodos; Leucemia Linfocítica Crônica de Células B/genética; Recidiva Local de Neoplasia/genética; Proteína Supressora de Tumor p53/genética; Adulto; Idoso; Feminino; Humanos; Leucemia Linfocítica Crônica de Células B/patologia; Masculino; Pessoa de Meia-Idade; Mutação; Recidiva Local de Neoplasia/patologia; Prognóstico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Proteína Supressora de Tumor p53 / Sequenciamento de Nucleotídeos em Larga Escala / Recidiva Local de Neoplasia Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido

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