Novel chemoselective (18)F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions.
Chem Commun (Camb)
; 52(36): 6083-6, 2016 May 04.
Article
em En
| MEDLINE
| ID: mdl-27043419
ABSTRACT
We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective (18)F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
Água
/
Compostos Radiofarmacêuticos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Suíça