[SEARCHING FOR NEW SYNTHETIC DIURETICS].
Eksp Klin Farmakol
; 78(12): 3-5, 2015.
Article
em Ru
| MEDLINE
| ID: mdl-27051919
ABSTRACT
This study was aimed at estimation of the diuretic and saluretic activity of 4-nitrophenyl-O-ß-D-glucopyranoside and its aglicon 4-nitrophenol in rats. Test animals daily received 4-nitrophenyl-O-ß-D-glucopyranoside (group 1) and 4-nitrophenol (group 2) intragastrically in 2 mL of distilled water in a dose of 18 µmol/kg from 1st to 7th day and 54 µmol/kg from 8th to 14th days. During the experiment, the most pronounced diuretic activity was observed for 4-nitrophenyl-O-ß-D-glucopyranoside in a dose of 54 µmol/kg, which increased the diuresis in rats 2.5 times as compared to the control value.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diurese
/
Diuréticos
/
Glucosídeos
/
Nitrofenóis
Limite:
Animals
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article