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RenalGuard System for the prevention of acute kidney injury in patients undergoing transcatheter aortic valve implantation.
Visconti, Gabriella; Focaccio, Amelia; Donahue, Michael; Golia, Bruno; Marzano, Antonio; Donnarumma, Elvira; Ricciardelli, Bruno; Selvetella, Lucio; Marino, Luigi; Briguori, Carlo.
Afiliação
  • Visconti G; Laboratory of Interventional Cardiology and Department of Cardiology, Clinica Mediterranea, Naples, Italy.
EuroIntervention ; 11(14): e1658-61, 2016 Apr 08.
Article em En | MEDLINE | ID: mdl-27056126
AIMS: We aimed to assess whether the RenalGuard™ System is effective in preventing acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). METHODS AND RESULTS: Forty-eight consecutive patients with chronic kidney disease (CKD) scheduled for TAVI were assigned to: 1) hydration with sodium bicarbonate solution (Control group), or 2) hydration with RenalGuard Therapy (RenalGuard group). Hypotension was defined as periprocedural mean blood pressure <55 mmHg. The primary endpoint was the occurrence of AKI (i.e., an increase of ≥0.3 mg/dL in the serum creatinine concentration at seven days). AKI occurred in 10/26 (38.5%) patients in the Control group and in 1/22 (4.5%) patients in the RenalGuard group (p=0.005, odds ratio [OR] 0.076, 95% confidence interval [CI]: 0.009-0.66). RenalGuard Therapy protected against AKI (OR 0.71, 95% CI: 0.07-0.775, p=0.026), whereas post-procedural hypotension (OR 3.88, 95% CI: 1.06-14.24, p=0.040), and contrast media volume (OR 3.65, 95% CI: 1.15-5.75, p=0.043) increased the risk of AKI. CONCLUSIONS: This non-randomised pilot study suggests that RenalGuard Therapy may be effective in preventing AKI in CKD patients undergoing TAVI.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estenose da Valva Aórtica / Implante de Prótese de Valva Cardíaca / Injúria Renal Aguda / Substituição da Valva Aórtica Transcateter Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: EuroIntervention Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / TERAPEUTICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estenose da Valva Aórtica / Implante de Prótese de Valva Cardíaca / Injúria Renal Aguda / Substituição da Valva Aórtica Transcateter Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Revista: EuroIntervention Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / TERAPEUTICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália