Melanoma cell-derived exosomes promote epithelial-mesenchymal transition in primary melanocytes through paracrine/autocrine signaling in the tumor microenvironment.

Xiao, Deyi; Barry, Samantha; Kmetz, Daniel; Egger, Michael; Pan, Jianmin; Rai, Shesh N; Qu, Jifu; McMasters, Kelly M; Hao, Hongying

Xiao, Deyi; Barry, Samantha; Kmetz, Daniel; Egger, Michael; Pan, Jianmin; Rai, Shesh N; Qu, Jifu; McMasters, Kelly M; Hao, Hongying.

Afiliação

Xiao D; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA.
Barry S; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA.
Kmetz D; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA.
Egger M; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA.
Pan J; Biostatistics Shared Facility, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.
Rai SN; Biostatistics Shared Facility, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY 40292, USA.
Qu J; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA.
McMasters KM; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA. Electronic address: kelly.mcmasters@louisville.edu.
Hao H; The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville School of Medicine, Kosair Charities Clinical & Translational Research Building, 505 S. Hancock St, Room 407, Louisville, KY 40292, USA. Electronic address: h0hao001@louisville.edu.

Cancer Lett ; 376(2): 318-27, 2016 07 01.

Article em En | MEDLINE | ID: mdl-27063098

Assuntos

Comunicação Autócrina; Transição Epitelial-Mesenquimal; Exossomos/metabolismo; Melanócitos/metabolismo; Melanoma/metabolismo; Comunicação Parácrina; Neoplasias Cutâneas/metabolismo; Microambiente Tumoral; Adulto; Idoso; Estudos de Casos e Controles; Linhagem Celular Tumoral; Feminino; Humanos; Masculino; Melanócitos/patologia; Melanoma/genética; Melanoma/secundário; MicroRNAs/genética; MicroRNAs/metabolismo; Pessoa de Meia-Idade; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Transdução de Sinais; Neoplasias Cutâneas/genética; Neoplasias Cutâneas/patologia; Transfecção

Palavras-chave

Epithelial-to-mesenchymal transition; Exosomes; Melanoma; Microenvironment; Paracrine/autocrine; Tumor progression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Comunicação Autócrina / Comunicação Parácrina / Exossomos / Transição Epitelial-Mesenquimal / Microambiente Tumoral / Melanócitos / Melanoma Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Lett Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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