Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker.

Zhang, Xuan; Tang, Kaiyong; Wang, Hong; Liu, Yaqian; Bao, Bin; Fang, Yanfen; Zhang, Xiongwen; Lu, Wei

Zhang, Xuan; Tang, Kaiyong; Wang, Hong; Liu, Yaqian; Bao, Bin; Fang, Yanfen; Zhang, Xiongwen; Lu, Wei.

Afiliação

Zhang X; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.
Tang K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences , Little Rock, Arkansas 72205, United States.
Wang H; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.
Liu Y; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.
Bao B; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.
Fang Y; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.
Zhang X; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.
Lu W; School of Chemistry and Molecular Engineering, East China Normal University , 3663 North Zhongshan Road, Shanghai 200062, PR China.

Bioconjug Chem ; 27(5): 1267-75, 2016 05 18.

Article em En | MEDLINE | ID: mdl-27070848

Assuntos

Antineoplásicos/química; Antineoplásicos/metabolismo; Camptotecina/química; Camptotecina/metabolismo; Catepsina B/metabolismo; Desenho de Fármacos; Nanopartículas; Animais; Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Transporte Biológico; Camptotecina/análogos & derivados; Camptotecina/síntese química; Camptotecina/farmacologia; Linhagem Celular Tumoral; Técnicas de Química Sintética; Estabilidade de Medicamentos; Humanos; Irinotecano; Camundongos; Pró-Fármacos/metabolismo; Solubilidade; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camptotecina / Catepsina B / Desenho de Fármacos / Nanopartículas / Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Bioconjug Chem Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article

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