[Liposomal cytarabine for the treatment of leptomeningeal dissemination of central nervous system tumours in children and adolescents]. / Citarabina liposomal para el tratamiento de la diseminación leptomeníngea en tumores del sistema nervioso central en niños y adolescentes.
An Pediatr (Barc)
; 85(5): 274.e1-274.e8, 2016 Nov.
Article
em Es
| MEDLINE
| ID: mdl-27086069
ABSTRACT
Leptomeningeal dissemination in paediatric central nervous system (CNS) tumours is associated with a poor outcome, and new therapeutic strategies are desperately needed. One of the main difficulties in the treatment of CNS tumours is blood brain barrier penetration. Intrathecal therapy has shown to be effective in several paediatric tumours. The aim of this article is to review the data available on the use of liposomal cytarabine for paediatric patients with leptomeningeal dissemination of CNS tumours, including the pharmacology, administration route, safety and efficacy data.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Sistema Nervoso Central
/
Citarabina
/
Neoplasias Meníngeas
/
Antimetabólitos Antineoplásicos
Limite:
Adolescent
/
Child
/
Humans
Idioma:
Es
Revista:
An Pediatr (Barc)
Assunto da revista:
PEDIATRIA
Ano de publicação:
2016
Tipo de documento:
Article