Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations.

Tholen, Stefan; Wolf, Cristina; Mayer, Bettina; Knopf, Julia D; Löffek, Stefanie; Qian, Yawen; Kizhakkedathu, Jayachandran N; Biniossek, Martin L; Franzke, Claus-Werner; Schilling, Oliver

Tholen, Stefan; Wolf, Cristina; Mayer, Bettina; Knopf, Julia D; Löffek, Stefanie; Qian, Yawen; Kizhakkedathu, Jayachandran N; Biniossek, Martin L; Franzke, Claus-Werner; Schilling, Oliver.

Afiliação

Tholen S; Institute of Molecular Medicine and Cell Research, University of Freiburg , 79104 Freiburg, Germany.
Wolf C; Department of Dermatology, University Medical Center Freiburg , 79104 Freiburg, Germany.
Mayer B; Institute of Molecular Medicine and Cell Research, University of Freiburg , 79104 Freiburg, Germany.
Knopf JD; Institute of Molecular Medicine and Cell Research, University of Freiburg , 79104 Freiburg, Germany.
Löffek S; Department of Dermatology, University Medical Center Freiburg , 79104 Freiburg, Germany.
Qian Y; Department of Dermatology, University Medical Center Freiburg , 79104 Freiburg, Germany.
Kizhakkedathu JN; Department of Pathology and Laboratory Medicine and Department of Chemistry, Centre for Blood Research, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.
Biniossek ML; Institute of Molecular Medicine and Cell Research, University of Freiburg , 79104 Freiburg, Germany.
Franzke CW; Department of Dermatology, University Medical Center Freiburg , 79104 Freiburg, Germany.
Schilling O; Institute of Molecular Medicine and Cell Research, University of Freiburg , 79104 Freiburg, Germany.

J Proteome Res ; 15(5): 1402-17, 2016 05 06.

Article em En | MEDLINE | ID: mdl-27089454

Assuntos

Proteína ADAM17/deficiência; Receptores ErbB/deficiência; Queratinócitos; Proteoma/metabolismo; Proteína ADAM17/genética; Animais; Epiderme/patologia; Receptores ErbB/genética; Deleção de Genes; Camundongos; Proteólise; Proteoma/análise

Palavras-chave

ADAM17; EGFR; TAILS; degradomics; ectodomain shedding; epidermal barrier formation; epidermis; filaggrin-2; proteases; proteomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Queratinócitos / Proteoma / Receptores ErbB / Proteína ADAM17 Limite: Animals Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

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