[Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease].
Sheng Li Xue Bao
; 68(2): 201-6, 2016 Apr 25.
Article
em Zh
| MEDLINE
| ID: mdl-27108908
ABSTRACT
microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Células Endoteliais
Limite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China