Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway.

Bode, Christian; Fox, Mario; Tewary, Poonam; Steinhagen, Almut; Ellerkmann, Richard K; Klinman, Dennis; Baumgarten, Georg; Hornung, Veit; Steinhagen, Folkert

Bode, Christian; Fox, Mario; Tewary, Poonam; Steinhagen, Almut; Ellerkmann, Richard K; Klinman, Dennis; Baumgarten, Georg; Hornung, Veit; Steinhagen, Folkert.

Afiliação

Bode C; Department of Anesthesiology and Critical Care Medicine, University of Bonn, Bonn, Germany.
Fox M; Department of Anesthesiology and Critical Care Medicine, University of Bonn, Bonn, Germany.
Tewary P; Laboratory of Experimental Immunology, Cancer Inflammation Program, Leidos Biomedical Research Inc, FNLCR, Frederick, MD, USA.
Steinhagen A; Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.
Ellerkmann RK; Department of Anesthesiology and Critical Care Medicine, University of Bonn, Bonn, Germany.
Klinman D; Cancer and Inflammation Program, Center for Cancer Research, NCI, Frederick, MD, USA.
Baumgarten G; Department of Anesthesiology and Critical Care Medicine, University of Bonn, Bonn, Germany.
Hornung V; Institute of Molecular Medicine, University of Bonn, Bonn, Germany.
Steinhagen F; Department of Anesthesiology and Critical Care Medicine, University of Bonn, Bonn, Germany.

Eur J Immunol ; 46(7): 1615-21, 2016 07.

Article em En | MEDLINE | ID: mdl-27125983

Assuntos

DNA/imunologia; Células Dendríticas/imunologia; Células Dendríticas/metabolismo; Interferon Tipo I/metabolismo; Proteínas de Membrana/metabolismo; Nucleotidiltransferases/metabolismo; Transdução de Sinais; Células Cultivadas; Citosol/imunologia; Citosol/metabolismo; Expressão Gênica; Humanos; Imunidade Inata; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Interferon Tipo I/genética; Proteínas de Membrana/genética; Nucleotidiltransferases/genética; Receptor Toll-Like 9/metabolismo

Palavras-chave

Cytosolic sensor; DNA; Dentritic cells; Innate immunity; Interferon; Toll-like-receptors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / DNA / Transdução de Sinais / Interferon Tipo I / Proteínas de Membrana / Nucleotidiltransferases Limite: Humans Idioma: En Revista: Eur J Immunol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

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