Dual roles of DNA repair enzymes in RNA biology/post-transcriptional control.
Wiley Interdiscip Rev RNA
; 7(5): 604-19, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27126972
ABSTRACT
Despite consistent research into the molecular principles of the DNA damage repair pathway for almost two decades, it has only recently been found that RNA metabolism is very tightly related to this pathway, and the two ancient biochemical mechanisms act in alliance to maintain cellular genomic integrity. The close links between these pathways are well exemplified by examining the base excision repair pathway, which is now well known for dual roles of many of its members in DNA repair and RNA surveillance, including APE1, SMUG1, and PARP1. With additional links between these pathways steadily emerging, this review aims to provide a summary of the emerging roles for DNA repair proteins in the post-transcriptional regulation of RNAs. WIREs RNA 2016, 7604-619. doi 10.1002/wrna.1353 For further resources related to this article, please visit the WIREs website.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Processamento Pós-Transcricional do RNA
/
Enzimas Reparadoras do DNA
Idioma:
En
Revista:
Wiley Interdiscip Rev RNA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Reino Unido