[Relationship between N-nitrosodimethylamine and risk of digestive tract cancers: a Meta analysis based on cohort studies].
Zhonghua Liu Xing Bing Xue Za Zhi
; 37(5): 725-9, 2016 May.
Article
em Zh
| MEDLINE
| ID: mdl-27188372
ABSTRACT
OBJECTIVE:
To analyze the relationship between N-nitrosodimethylamine(NDMA)and the risk of digestive tract cancers.METHODS:
The papers about the relationship between NDMA and the risk of digestive tract cancers published from 1980 to 2012 were retrieved following databases Chinese BioMedical Literature Database(CBM), the Chinese Journal Full-text Database(CNKI), Wanfang Database, PubMed and EBSCO. The fix and random effect model was used and statistical analyses were conducted by using RevMan 5.1 software.RESULTS:
Thirteen papers were found, in which 7 about digestive tract cancers were used in this Meta analysis. The NDMA had significant positive effect on the incidence of digestive tract cancers(RR=1.12, 95% CI 1.03-1.21). The relationship between NDMA and esophageal cancer was not significant(RR=1.18, 95%CI 0.98-1.41)but NDMA could increase the risk of gastric cancer(RR=1.08, 95% CI 1.00-1.18). For the subtypes of esophageal and gastric cancer, NDMA had positive relationship with esophageal squamous cell carcinoma(RR=1.72, 95% CI 1.01-2.96), but had no significant relationship with esophageal adenocarcinoma, cardiac carcinoma and gastric adenocarcinoma.CONCLUSION:
The population-based cohort studies have showed that the NDMA could significantly increase the risk of digestive tract cancers, but the effects differed with subtypes of esophageal and gastric cancer. However, it is necessary to collect more evidence due to the limited studies and obvious differences in the study design, sampling and exposure measurement of these cohort studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Povo Asiático
/
Neoplasias do Sistema Digestório
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Dimetilnitrosamina
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Neoplasias Gastrointestinais
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
/
Systematic_reviews
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Zhonghua Liu Xing Bing Xue Za Zhi
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China