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Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.
Krejcik, Jakub; Casneuf, Tineke; Nijhof, Inger S; Verbist, Bie; Bald, Jaime; Plesner, Torben; Syed, Khaja; Liu, Kevin; van de Donk, Niels W C J; Weiss, Brendan M; Ahmadi, Tahamtan; Lokhorst, Henk M; Mutis, Tuna; Sasser, A Kate.
Afiliação
  • Krejcik J; Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands; Institute of Regional Health Science and Department of Hematology, Sections of Internal Medicine, Vejle Hospital and University of Southern Denmark, Vejle, Denmark;
  • Casneuf T; Janssen Research & Development, Beerse, Belgium;
  • Nijhof IS; Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;
  • Verbist B; Janssen Research & Development, Beerse, Belgium;
  • Bald J; Janssen Research & Development, LLC, Spring House, PA;
  • Plesner T; Institute of Regional Health Science and Department of Hematology, Sections of Internal Medicine, Vejle Hospital and University of Southern Denmark, Vejle, Denmark;
  • Syed K; Janssen Research & Development, LLC, Spring House, PA;
  • Liu K; Janssen Research & Development, LLC, Raritan, NJ; and.
  • van de Donk NW; Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;
  • Weiss BM; Division of Hematology-Oncology, Department of Medicine, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Ahmadi T; Janssen Research & Development, LLC, Spring House, PA;
  • Lokhorst HM; Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;
  • Mutis T; Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands;
  • Sasser AK; Janssen Research & Development, LLC, Spring House, PA;
Blood ; 128(3): 384-94, 2016 07 21.
Article em En | MEDLINE | ID: mdl-27222480
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Linfócitos T Reguladores / Linfócitos T CD8-Positivos / ADP-Ribosil Ciclase 1 / Anticorpos Monoclonais / Mieloma Múltiplo / Proteínas de Neoplasias Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Blood Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Linfócitos T Reguladores / Linfócitos T CD8-Positivos / ADP-Ribosil Ciclase 1 / Anticorpos Monoclonais / Mieloma Múltiplo / Proteínas de Neoplasias Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Blood Ano de publicação: 2016 Tipo de documento: Article