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Differential quantification of isobaric phosphopeptides using data-independent acquisition mass spectrometry.
Sidoli, Simone; Fujiwara, Rina; Kulej, Katarzyna; Garcia, Benjamin A.
Afiliação
  • Sidoli S; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Room 9-124, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USA. bgarci@mail.med.upenn.edu.
  • Fujiwara R; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Room 9-124, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USA. bgarci@mail.med.upenn.edu.
  • Kulej K; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Room 9-124, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USA. bgarci@mail.med.upenn.edu and Division of Cancer Pathobiology, The Children's Hospital of Philadelphia,
  • Garcia BA; Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Room 9-124, 3400 Civic Center Blvd, Bldg 421, Philadelphia, PA 19104, USA. bgarci@mail.med.upenn.edu.
Mol Biosyst ; 12(8): 2385-8, 2016 07 19.
Article em En | MEDLINE | ID: mdl-27301801
ABSTRACT
Phosphorylation is a post-translational modification (PTM) fundamental for processes such as signal transduction and enzyme activity. We propose to apply data-independent acquisition (DIA) using mass spectrometry (MS) to determine unexplored phosphorylation events on isobarically modified peptides. Such peptides are commonly not quantitatively discriminated in phosphoproteomics due to their identical mass.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfopeptídeos / Espectrometria de Massas Idioma: En Revista: Mol Biosyst Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfopeptídeos / Espectrometria de Massas Idioma: En Revista: Mol Biosyst Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos