Impact of Weight Extremes on Clinical Outcomes in Pediatric Acute Respiratory Distress Syndrome.
Crit Care Med
; 44(11): 2052-2059, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27355525
ABSTRACT
OBJECTIVES:
To determine whether weight extremes impact clinical outcomes in pediatric acute respiratory distress syndrome.DESIGN:
Post hoc analysis of a cohort created by combining five multicenter pediatric acute respiratory distress syndrome studies.SETTING:
Forty-three academic PICUs worldwide. PATIENTS A total of 711 subjects prospectively diagnosed with pediatric acute respiratory distress syndrome. INTERVENTION Subjects more than 2 years were included and categorized by Center for Disease Control and Prevention body mass index z score criteria underweight (< -1.89), normal weight (-1.89 to +1.04), overweight (+1.05 to +1.64), and obese (≥ +1.65). Subjects were stratified by direct versus indirect lung injury leading to pediatric acute respiratory distress syndrome. The primary outcome was in-hospital mortality. In survivors, secondary analyses included duration of mechanical ventilation and ICU length of stay. MEASUREMENTS AND MAINRESULTS:
A total of 331 patients met inclusion criteria; 12% were underweight, 50% normal weight, 11% overweight, and 27% obese. Overall mortality was 20%. By multivariate analysis, body mass index category was independently associated with mortality (p = 0.004). When stratified by lung injury type, there was no mortality difference between body mass index groups with direct lung injury; however, in the indirect lung injury group, the odds of mortality in the obese were significantly lower than normal weight subjects (odds ratio, 0.11; 95% CI, 0.02-0.84). Survivors with direct lung injury had no difference in the duration of mechanical ventilation or ICU length of stay; however, those with indirect lung injury, the overweight required longer duration of mechanical ventilation than other groups (p < 0.001).CONCLUSIONS:
These data support the obesity paradox in pediatric acute respiratory distress syndrome. Obese children with indirect lung injury pediatric acute respiratory distress syndrome have a lower risk of mortality. Importantly, among survivors, the overweight with indirect lung injury requires longer duration of mechanical ventilation. Our data require prospective validation to further elucidate the pathobiology of this phenomenon.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Respiratória
/
Índice de Massa Corporal
/
Tempo de Internação
Tipo de estudo:
Clinical_trials
Limite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Crit Care Med
Ano de publicação:
2016
Tipo de documento:
Article