[ZNF143 is involved in CTCF-mediated chromatin interactions by cooperation with cohesin and other partners].
Mol Biol (Mosk)
; 50(3): 496-503, 2016.
Article
em Ru
| MEDLINE
| ID: mdl-27414788
ABSTRACT
ZNF143 is a ubiquitously expressed transcription factor conserved in vertebrates and might regulate the expression of numerous genes. But its function in mediating chromatin interactions remains elusive. By integrated analysis of public datasets, we provided evidence that a majority of ZNF143 binding sites (BSs) were involved in CTCF-mediated chromatin interaction networks (CTCF-CINs) by overlapping with cohesin-BSs and CTCF-BSs. We further showed that only a very few CTCF-CINs were associated with ZNF143 alone, whereas those associated with ZNF143 and cohesin simultaneously were highly overlapped with constitutive, conserved CTCF-BSs and enriched at boundaries of chromatin topologically associating domains. These observations implicate that as an important partner of CTCF, ZNF143 helps it establish the conserved chromatin structure by cooperating with cohesin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Cromatina
/
Proteínas Cromossômicas não Histona
/
Transativadores
/
Proteínas de Ciclo Celular
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ru
Revista:
Mol Biol (Mosk)
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China