[The role of mitochondrial permeability transition pore in the occurrence of septic myocardial depression].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
; 28(8): 747-51, 2016 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-27434571
ABSTRACT
OBJECTIVE:
Sepsis is defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection and septic myocardial depression (SMD) is a common complication. Pathogenesis of SMD is complicated and there is lack of specific treatment. Mitochondrial damage is an important pathological basis of SMD, and mitochondrial permeability transition pore (MPTP) plays an important role in maintaining the normal structure and function of the mitochondria. The change of MPTP during sepsis is summarized in this review so as to reveal the significant mechanism of MPTP in the occurrence of SMD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Proteínas de Transporte da Membrana Mitocondrial
/
Coração
/
Mitocôndrias
Limite:
Humans
Idioma:
Zh
Revista:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Ano de publicação:
2016
Tipo de documento:
Article