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Discovery of novel potent imidazo[1,2-b]pyridazine PDE10a inhibitors.
Meegalla, Sanath K; Huang, Hui; Illig, Carl R; Parks, Daniel J; Chen, Jinsheng; Lee, Yu-Kai; Wilson, Kenneth J; Patel, Sharmila K; Cheung, Wing S; Lu, Tianbao; Kirchner, Thomas; Askari, Hossein B; Geisler, John; Patch, Raymond J; Gibbs, Alan C; Rady, Brian; Connelly, Margery; Player, Mark R.
Afiliação
  • Meegalla SK; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Huang H; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Illig CR; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Parks DJ; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Chen J; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Lee YK; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Wilson KJ; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Patel SK; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Cheung WS; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Lu T; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Kirchner T; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Askari HB; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Geisler J; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Patch RJ; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Gibbs AC; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Rady B; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Connelly M; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
  • Player MR; Janssen Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA. Electronic address: mplayer@its.jnj.com.
Bioorg Med Chem Lett ; 26(17): 4216-22, 2016 09 01.
Article em En | MEDLINE | ID: mdl-27491708
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Piridinas / Desenho de Fármacos / Diester Fosfórico Hidrolases / Imidazóis Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Piridinas / Desenho de Fármacos / Diester Fosfórico Hidrolases / Imidazóis Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos