A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation.

Padua, David; Mahurkar-Joshi, Swapna; Law, Ivy Ka Man; Polytarchou, Christos; Vu, John P; Pisegna, Joseph R; Shih, David; Iliopoulos, Dimitrios; Pothoulakis, Charalabos

Padua, David; Mahurkar-Joshi, Swapna; Law, Ivy Ka Man; Polytarchou, Christos; Vu, John P; Pisegna, Joseph R; Shih, David; Iliopoulos, Dimitrios; Pothoulakis, Charalabos.

Afiliação

Padua D; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;
Mahurkar-Joshi S; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;
Law IK; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;
Polytarchou C; Center for Systems Biomedicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom;
Vu JP; Division of Gastroenterology, Hepatology and Parenteral Nutrition, VA Greater Los Angeles Healthcare System and Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and.
Pisegna JR; Division of Gastroenterology, Hepatology and Parenteral Nutrition, VA Greater Los Angeles Healthcare System and Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and.
Shih D; Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Iliopoulos D; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; Center for Systems Biomedicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California;
Pothoulakis C; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; cpothoulakis@mednet.ucla.edu.

Am J Physiol Gastrointest Liver Physiol ; 311(3): G446-57, 2016 09 01.

Article em En | MEDLINE | ID: mdl-27492330

Assuntos

Colite Ulcerativa/metabolismo; Regulação da Expressão Gênica/fisiologia; Inflamação/metabolismo; Interferon gama/metabolismo; RNA Longo não Codificante/metabolismo; RNA Mensageiro/metabolismo; Adulto; Idoso; Animais; Estudos de Casos e Controles; Feminino; Humanos; Interferon gama/genética; Interleucina-10/genética; Interleucina-10/metabolismo; Células Jurkat; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Pessoa de Meia-Idade; RNA Longo não Codificante/genética; RNA Mensageiro/genética

Palavras-chave

inflammation; inflammatory bowel disease; interferon Î³; lncRNA; ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Colite Ulcerativa / Regulação da Expressão Gênica / Interferon gama / RNA Longo não Codificante / Inflamação Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Assunto da revista: FISIOLOGIA / GASTROENTEROLOGIA Ano de publicação: 2016 Tipo de documento: Article

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