Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells.

Sun, Alfred Xuyang; Yuan, Qiang; Tan, Shawn; Xiao, Yixin; Wang, Danlei; Khoo, Audrey Tze Ting; Sani, Levena; Tran, Hoang-Dai; Kim, Paul; Chiew, Yong Seng; Lee, Kea Joo; Yen, Yi-Chun; Ng, Huck Hui; Lim, Bing; Je, Hyunsoo Shawn

Sun, Alfred Xuyang; Yuan, Qiang; Tan, Shawn; Xiao, Yixin; Wang, Danlei; Khoo, Audrey Tze Ting; Sani, Levena; Tran, Hoang-Dai; Kim, Paul; Chiew, Yong Seng; Lee, Kea Joo; Yen, Yi-Chun; Ng, Huck Hui; Lim, Bing; Je, Hyunsoo Shawn.

Afiliação

Sun AX; Cancer Stem Cell Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Stem Cell and Regenerative Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Department of Neurology, National Neuroscience Institute, 20 College Road, Sin
Yuan Q; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Graduate School for integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.
Tan S; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Graduate School for integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.
Xiao Y; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Wang D; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Khoo AT; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Sani L; Cancer Stem Cell Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
Tran HD; Stem Cell and Regenerative Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
Kim P; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Chiew YS; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Lee KJ; Department of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu 701-300, Republic of Korea.
Yen YC; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.
Ng HH; Stem Cell and Regenerative Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore; Graduate School for integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore.
Lim B; Cancer Stem Cell Biology, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore.
Je HS; Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. Electronic

Cell Rep ; 16(7): 1942-53, 2016 08 16.

Article em En | MEDLINE | ID: mdl-27498872

Assuntos

Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Córtex Cerebral/metabolismo; Neurônios GABAérgicos/metabolismo; Células-Tronco Pluripotentes/metabolismo; Prosencéfalo/metabolismo; Ácido gama-Aminobutírico/metabolismo; Animais; Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo; Biomarcadores/metabolismo; Diferenciação Celular; Linhagem Celular; Córtex Cerebral/citologia; Técnicas de Cocultura; Neurônios GABAérgicos/citologia; Expressão Gênica; Proteínas de Homeodomínio/genética; Proteínas de Homeodomínio/metabolismo; Humanos; Interneurônios/citologia; Interneurônios/metabolismo; Proteínas com Homeodomínio LIM/genética; Proteínas com Homeodomínio LIM/metabolismo; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Proteínas do Tecido Nervoso/genética; Proteínas do Tecido Nervoso/metabolismo; Células-Tronco Neurais/citologia; Células-Tronco Neurais/metabolismo; Neuroglia/citologia; Neuroglia/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Técnicas de Patch-Clamp; Células-Tronco Pluripotentes/citologia; Cultura Primária de Células; Prosencéfalo/citologia; Sinapses/fisiologia; Transmissão Sináptica/fisiologia; Fator Nuclear 1 de Tireoide; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

Palavras-chave

GABA; direct conversion; human pluripotent stem cells; interneuron; synapse

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Cerebral / Prosencéfalo / Células-Tronco Pluripotentes / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Neurônios GABAérgicos / Ácido gama-Aminobutírico Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Cell Rep Ano de publicação: 2016 Tipo de documento: Article

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