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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Daniels, Michael J D; Rivers-Auty, Jack; Schilling, Tom; Spencer, Nicholas G; Watremez, William; Fasolino, Victoria; Booth, Sophie J; White, Claire S; Baldwin, Alex G; Freeman, Sally; Wong, Raymond; Latta, Clare; Yu, Shi; Jackson, Joshua; Fischer, Nicolas; Koziel, Violette; Pillot, Thierry; Bagnall, James; Allan, Stuart M; Paszek, Pawel; Galea, James; Harte, Michael K; Eder, Claudia; Lawrence, Catherine B; Brough, David.
Afiliação
  • Daniels MJ; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Rivers-Auty J; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Schilling T; St. George's University of London, Institute for Infection and Immunity, Cranmer Terrace, London SW17 0RE, UK.
  • Spencer NG; St. George's University of London, Institute for Infection and Immunity, Cranmer Terrace, London SW17 0RE, UK.
  • Watremez W; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.
  • Fasolino V; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.
  • Booth SJ; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • White CS; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Baldwin AG; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.
  • Freeman S; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.
  • Wong R; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Latta C; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Yu S; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Jackson J; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.
  • Fischer N; SynAging SAS, 24-30 rue Lionnois, Nancy F-54000, France.
  • Koziel V; SynAging SAS, 24-30 rue Lionnois, Nancy F-54000, France.
  • Pillot T; SynAging SAS, 24-30 rue Lionnois, Nancy F-54000, France.
  • Bagnall J; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Allan SM; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Paszek P; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Galea J; Division of Neuroscience, Ninewells Medical School, University of Dundee, Dundee DD1 9SY, UK.
  • Harte MK; Manchester Pharmacy School, University of Manchester, Manchester M13 9PT, UK.
  • Eder C; St. George's University of London, Institute for Infection and Immunity, Cranmer Terrace, London SW17 0RE, UK.
  • Lawrence CB; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
  • Brough D; Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.
Nat Commun ; 7: 12504, 2016 08 11.
Article em En | MEDLINE | ID: mdl-27509875
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anti-Inflamatórios não Esteroides / Ácido Flufenâmico / Ácido Mefenâmico / Inflamassomos / Doença de Alzheimer / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anti-Inflamatórios não Esteroides / Ácido Flufenâmico / Ácido Mefenâmico / Inflamassomos / Doença de Alzheimer / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido