The ROCK/GGTase Pathway Are Essential to the Proliferation and Differentiation of Neural Stem Cells Mediated by Simvastatin.

Zhang, Chan; Wu, Jian-Min; Liao, Min; Wang, Jun-Ling; Xu, Chao-Jin

Zhang, Chan; Wu, Jian-Min; Liao, Min; Wang, Jun-Ling; Xu, Chao-Jin.

Afiliação

Zhang C; School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Wu JM; Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Liao M; Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Cha Shan, University Town, Wenzhou, Zhejiang, 325035, China.
Wang JL; Department of Clinical Laboratory, Fudan University Affiliated Huadong Hospital, Shanghai, 200040, China. Wangliujunling@163.com.
Xu CJ; Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Cha Shan, University Town, Wenzhou, Zhejiang, 325035, China. xuzhaojin@gmail.com.

J Mol Neurosci ; 60(4): 474-485, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27541019

Assuntos

Alquil e Aril Transferases/metabolismo; Anticolesterolemiantes/farmacologia; Proliferação de Células; Células-Tronco Neurais/metabolismo; Neurogênese; Sinvastatina/farmacologia; Quinases Associadas a rho/metabolismo; Alquil e Aril Transferases/antagonistas & inibidores; Animais; Ciclo Celular; Células Cultivadas; Células-Tronco Neurais/citologia; Células-Tronco Neurais/efeitos dos fármacos; Células-Tronco Neurais/fisiologia; Inibidores de Proteínas Quinases/farmacologia; Ratos; Ratos Sprague-Dawley; Quinases Associadas a rho/antagonistas & inibidores

Palavras-chave

GGTase; Neural stem cells; ROCK; Simvastatin

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinvastatina / Alquil e Aril Transferases / Proliferação de Células / Quinases Associadas a rho / Neurogênese / Células-Tronco Neurais / Anticolesterolemiantes Limite: Animals Idioma: En Revista: J Mol Neurosci Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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