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An S-warfarin and AZD1981 interaction: in vitro and clinical pilot data suggest the N-deacetylated amino acid metabolite as the primary perpetrator.
Grime, Ken; Pehrson, Rikard; Nordell, Pär; Gillen, Michael; Kühn, Wolfgang; Mant, Timothy; Brännström, Marie; Svanberg, Petter; Jones, Barry; Brealey, Clive.
Afiliação
  • Grime K; Respiratory, Inflammation & Autoimmune Disease Department of DMPK, AstraZeneca R&D, Gothenburg, Sweden.
  • Pehrson R; Respiratory, Inflammation & Autoimmune Disease Department of DMPK, AstraZeneca R&D, Gothenburg, Sweden.
  • Nordell P; Drug Safety and Metabolism, AstraZeneca R&D, Gothenburg, Sweden.
  • Gillen M; AstraZeneca Early Clinical Development, Gaithersburg, MD, USA.
  • Kühn W; Quintiles Allergy, Respiratory, Infectious Diseases & Vaccines Therapeutic Science & Strategy Unit, Uppsala, Sweden.
  • Mant T; Quintiles Drug Research Unit at Guy's Hospital, London, UK.
  • Brännström M; Respiratory, Inflammation & Autoimmune Disease Department of DMPK, AstraZeneca R&D, Gothenburg, Sweden.
  • Svanberg P; Respiratory, Inflammation & Autoimmune Disease Department of DMPK, AstraZeneca R&D, Gothenburg, Sweden.
  • Jones B; Drug Safety and Metabolism, AstraZeneca R&D, Gothenburg, Sweden.
  • Brealey C; Roche DMPK, Basel, Switzerland.
Br J Clin Pharmacol ; 83(2): 381-392, 2017 02.
Article em En | MEDLINE | ID: mdl-27558866
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Varfarina / Hepatócitos / Inibidores do Citocromo P-450 CYP2C9 / Indóis / Acetatos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Varfarina / Hepatócitos / Inibidores do Citocromo P-450 CYP2C9 / Indóis / Acetatos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Suécia