Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-Î³ ligands in a cyclooxygenase-2-dependent manner.

Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H; Maddipati, Krishna Rao; Honn, Kenneth V; Sime, Patricia J; Phipps, Richard P

Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H; Maddipati, Krishna Rao; Honn, Kenneth V; Sime, Patricia J; Phipps, Richard P.

Afiliação

Lacy SH; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Woeller CF; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Thatcher TH; Division of Pulmonary Diseases and Critical Care, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Maddipati KR; Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Honn KV; Lipidomics Core Facility, Department of Pathology, Bioactive Lipids Research Program, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, Michigan; and.
Sime PJ; Bioactive Lipids Research Program, Department of Pathology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, Michigan.
Phipps RP; Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.

Am J Physiol Lung Cell Mol Physiol ; 311(5): L855-L867, 2016 Nov 01.

Article em En | MEDLINE | ID: mdl-27612965

Assuntos

Ciclo-Oxigenase 2/metabolismo; Fibroblastos/metabolismo; Pulmão/citologia; PPAR gama/metabolismo; Ácidos Araquidônicos/farmacologia; Meios de Cultivo Condicionados/farmacologia; Dinoprostona/metabolismo; Eicosanoides/metabolismo; Feminino; Fibroblastos/efeitos dos fármacos; Fibroblastos/enzimologia; Células HEK293; Humanos; Mediadores da Inflamação/metabolismo; Interleucina-1beta/farmacologia; Interleucina-6/metabolismo; Interleucina-8/metabolismo; Oxirredutases Intramoleculares/metabolismo; Ligantes; Lipocalinas/metabolismo; Masculino; NF-kappa B/metabolismo; Prostaglandina-E Sintases; Fumar; Regulação para Cima/efeitos dos fármacos

Palavras-chave

NFκB; lipidomics; peroxisome proliferator-activated receptor-Î³; primary human lung fibroblasts; specialized proresolving mediators

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: PPAR gama / Ciclo-Oxigenase 2 / Fibroblastos / Pulmão Limite: Female / Humans / Male Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Assunto da revista: BIOLOGIA MOLECULAR / FISIOLOGIA Ano de publicação: 2016 Tipo de documento: Article

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