ß-Cell replacement as a treatment for type 1 diabetes: an overview of possible cell sources and current axes of research.
Diabetes Obes Metab
; 18 Suppl 1: 137-43, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27615143
ABSTRACT
To efficiently treat type 1 diabetes, exogenous insulin injections currently represent the main approach to counter chronic hyperglycaemia. Unfortunately, such a therapeutic approach does not allow for perfectly maintained glucose homeostasis and, in time, cardiovascular complications may arise. Therefore, seeking alternative/improved treatments has become a major health concern as an increasing proportion of type 2 diabetes patients also require insulin supplementation. Towards this goal, numerous laboratories have focused their research on ß-cell replacement therapies. Herein, we will review the current state of this research area and describe the cell sources that could potentially be used to replenish the depleted ß-cell mass in diabetic patients.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
/
Células Secretoras de Insulina
/
Células-Tronco Pluripotentes Induzidas
/
Terapia Baseada em Transplante de Células e Tecidos
/
Células-Tronco Embrionárias Humanas
Limite:
Humans
Idioma:
En
Revista:
Diabetes Obes Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França