Synthesis of Unprecedented Sulfonylated Phosphono-exo-Glycals Designed as Inhibitors of the Three Mycobacterial Galactofuranose Processing Enzymes.

Frédéric, Christophe J-M; Tikad, Abdellatif; Fu, Jian; Pan, Weidong; Zheng, Ruixiang B; Koizumi, Akihiko; Xue, Xiaochao; Lowary, Todd L; Vincent, Stéphane P

Frédéric, Christophe J-M; Tikad, Abdellatif; Fu, Jian; Pan, Weidong; Zheng, Ruixiang B; Koizumi, Akihiko; Xue, Xiaochao; Lowary, Todd L; Vincent, Stéphane P.

Afiliação

Frédéric CJ; University of Namur (UNamur), Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000, Namur, Belgium.
Tikad A; University of Namur (UNamur), Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000, Namur, Belgium.
Fu J; University of Namur (UNamur), Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000, Namur, Belgium.
Pan W; The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, 202, Sha-chong South Road, Guiyang, 550002, P. R. China.
Zheng RB; Department of Chemistry and Alberta Glycomics Centre, University of Alberta, Gunning-Lemieux Chemistry Centre, 11227 Saskatchewan Drive, Edmonton, AB T6G 2G2, Canada.
Koizumi A; Department of Chemistry and Alberta Glycomics Centre, University of Alberta, Gunning-Lemieux Chemistry Centre, 11227 Saskatchewan Drive, Edmonton, AB T6G 2G2, Canada.
Xue X; Department of Chemistry and Alberta Glycomics Centre, University of Alberta, Gunning-Lemieux Chemistry Centre, 11227 Saskatchewan Drive, Edmonton, AB T6G 2G2, Canada.
Lowary TL; Department of Chemistry and Alberta Glycomics Centre, University of Alberta, Gunning-Lemieux Chemistry Centre, 11227 Saskatchewan Drive, Edmonton, AB T6G 2G2, Canada.
Vincent SP; University of Namur (UNamur), Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, 5000, Namur, Belgium. stephane.vincent@unamur.be.

Chemistry ; 22(44): 15913-15920, 2016 Oct 24.

Article em En | MEDLINE | ID: mdl-27628709

Assuntos

Carboidratos/síntese química; Éteres/química; Mycobacterium/química; Difosfato de Uridina/química; Carboidratos/química; Estereoisomerismo

Palavras-chave

glycals; glycosyltransferase; phosphonates; sulfones; tuberculosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Difosfato de Uridina / Carboidratos / Éteres / Mycobacterium Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Bélgica

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