Liposome encapsulated perfluorohexane enhances radiotherapy in mice without additional oxygen supply.
J Transl Med
; 14: 268, 2016 09 20.
Article
em En
| MEDLINE
| ID: mdl-27646172
BACKGROUND: To investigate the effect of perfluorochemical preparations in enhancing radiotherapy, perfluocarbon nanoparticles were by encapsulating perfluorohexane into liposome [lip(PFH)]. METHODS: After intravenous injection, lip(PFH) could accumulate in the tumor site over time, with a prominent accumulation in tumor 24 h post injection. X-ray was delivered to the tumor site 24 h after the injection of lip(PFH) under room air. The experimental mice were randomized into four groups: control (saline), lip(PFH) (lip(PFH) only), X-ray (X-ray only), and lip(PFH) + X-ray (lip(PFH) with X-ray radiation). Tumor volume and histology were monitored to assess treatment efficacy. RESULTS: Tumor growth was significantly reduced in mice received lip(PFH) and X-ray compared with X-ray only. The histological data also revealed more destruction of tumor tissue in lip(PFH) + X-ray group compared with X-ray only. In addition, lip(PFH) did not show any significant tissue damage to major organs or induce significant liver/kidney dysfunction. CONCLUSIONS: Lip(PFH) could accumulate in the tumor site and enhance radiotherapy without additional oxygen supply.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Neoplasias do Colo
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Nanopartículas
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Fluorocarbonos
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Lipossomos
Limite:
Animals
Idioma:
En
Revista:
J Transl Med
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China