Xanthium strumarium as an Inhibitor of α-Glucosidase, Protein Tyrosine Phosphatase 1ß, Protein Glycation and ABTS⺠for Diabetic and Its Complication.
Molecules
; 21(9)2016 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-27649132
ABSTRACT
Phytochemical investigation of the natural products from Xanthium strumarium led to the isolation of fourteen compounds including seven caffeoylquinic acid (CQA) derivatives. The individual compounds were screened for inhibition of α-glucosidase, protein tyrosine phosphatase 1ß (PTP1ß), advanced glycation end products (AGEs), and ABTS⺠radical scavenging activity using in vitro assays. Among the isolated compounds, methyl-3,5-di-caffeoyquinic acid exhibited significant inhibitory activity against α-glucosidase (18.42 µM), PTP1ß (1.88 µM), AGEs (82.79 µM), and ABTS⺠(6.03 µM). This effect was marked compared to that of the positive controls (acarbose 584.79 µM, sumarin 5.51 µM, aminoguanidine 1410.00 µM, and trolox 29.72 µM respectively). In addition, 3,5-di-O-CQA (88.14 µM) and protocatechuic acid (32.93 µM) had a considerable inhibitory effect against α-glucosidase and ABTSâº. Based on these findings, methyl-3,5-di-caffeoyquinic acid was assumed to be potentially responsible for the anti-diabetic actions of X. strumarium.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
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Ácidos Sulfônicos
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Proteínas de Saccharomyces cerevisiae
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Xanthium
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Benzotiazóis
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Alfa-Glucosidases
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Proteína Tirosina Fosfatase não Receptora Tipo 1
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Inibidores de Glicosídeo Hidrolases
Limite:
Animals
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Humans
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article