Human CalDAG-GEFI deficiency increases bleeding and delays &#945;IIbß3 activation.

Kato, Hisashi; Nakazawa, Yozo; Kurokawa, Yumi; Kashiwagi, Hirokazu; Morikawa, Yoichiro; Morita, Daisuke; Banno, Fumiaki; Honda, Shigenori; Kanakura, Yuzuru; Tomiyama, Yoshiaki

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbß3 activation.

Kato, Hisashi; Nakazawa, Yozo; Kurokawa, Yumi; Kashiwagi, Hirokazu; Morikawa, Yoichiro; Morita, Daisuke; Banno, Fumiaki; Honda, Shigenori; Kanakura, Yuzuru; Tomiyama, Yoshiaki.

Afiliação

Kato H; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Nakazawa Y; Department of Pediatrics, and.
Kurokawa Y; Department for the Promotion of Regional Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Kashiwagi H; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Morikawa Y; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Morita D; Department of Pediatrics, and.
Banno F; Department of Food and Nutrition, Koriyama Women's University, Koriyama, Japan.
Honda S; Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan; and.
Kanakura Y; Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Tomiyama Y; Department of Blood Transfusion, Osaka University Hospital, Osaka, Japan.

Blood ; 128(23): 2729-2733, 2016 12 08.

Article em En | MEDLINE | ID: mdl-27663674

Assuntos

Plaquetas/metabolismo; Fatores de Troca do Nucleotídeo Guanina/deficiência; Hemorragia; Mutação de Sentido Incorreto; Complexo Glicoproteico GPIIb-IIIa de Plaquetas/metabolismo; Adolescente; Substituição de Aminoácidos; Animais; Plaquetas/patologia; Feminino; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Hemorragia/genética; Hemorragia/metabolismo; Hemorragia/patologia; Humanos; Camundongos; Camundongos Knockout; Complexo Glicoproteico GPIIb-IIIa de Plaquetas/genética

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Complexo Glicoproteico GPIIb-IIIa de Plaquetas / Mutação de Sentido Incorreto / Fatores de Troca do Nucleotídeo Guanina / Hemorragia Tipo de estudo: Prognostic_studies Limite: Adolescent / Animals / Female / Humans Idioma: En Revista: Blood Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

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